[MEGAFRAME] 2010: MEGAFRAME was successfully completed (see also MEGAFRAME Final Report , MEGAFRAME D6.4 Laboratory fluorescence microscopy demonstrator ), but work using the MEGAFRAME32 (32x32) and MEGAFRAME128 (128x160) devices has continued, as you can also see from the Publications section.

MEGAFRAME32 is being distributed by Photon Force Ltd (contact: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it ).

In parallel, the follow-up FP7 ICT SPADnet project ( ) has been launched, dedicated to the use of SPAD arrays in medical imaging, most notably Positron Emission Tomography (PET), building on the MEGAFRAME scientific and technological achievements.


[MEGAFRAME] April 2010: MEGAFRAME was selected as one of "12 outstanding Commission-funded FET projects" showcased at the European Parliament in Strasbourg within the Science beyond Fiction exhibition, 20-21 April 2010, organised to introduce Members of the European Parliament to Future and Emerging Technologies (FET). E. Charbon [and J. Arlt] attended and presented a 3 part poster (poster 1 - poster 2 - poster 3). 


[MEGAFRAME] Oct. 2009: MEGAFRAME reports on the performance of an array of 32x32 plano-convex 50μm pitch microlenses (see LEOS 2009), fabricated by co-polymer casting in a photoresist replica mold, which have been characterized by a specially developed Optical Test Bench. The measured detection sensitivity increase reaches up to a factor of 35. This concentration factor is, to the best of our knowledge, presently the highest reported to date for any array of SPADs.


[MEGAFRAME] Sept. 2009: S. Donati, UNIPV, has been invited to present a talk at the 17th International Conference on Advanced Laser Technologies (ALT09), 26 Sept - 1 Oct 2009, Antalya, Turkey, and selected the MEGAFRAME project as a topic.


[MEGAFRAME] June-Sept. 2009: MEGAFRAME reports on the design and characterisation of 32x32 TDC/TAC plus single photon avalanche diode (SPAD) pixel arrays implemented in a 130nm imaging process, to create a single chip TCSPC sensor (see the IISW, CICC and ESSDERC Publications). To the best of our knowledge, this work constitutes the largest single-chip array of fully integrated TDCs/TACs so far reported. Each TDC/TAC-SPAD ensemble measures only 50x50μm2. It is thus one of the smallest ever demonstrated with deep sub-nanosecond time resolution.


[European R&D] July 2009: The European Commission has explicitly included single-photon and smart pixel based time-correlated imaging R&D into the ICT Call 5 Photonics 2009 topics (see EC Photonics unit website). This is fully in line with MEGAFRAME’s pioneering results, which proved that single photon arrays can indeed be implemented in deep sub-micron CMOS for time-correlated as well as intensity applications.


[MEGAFRAME] July 2009: MEGAFRAME reports on the a new low noise single-photon avalanche diode (SPAD) fabricated in a 130 nm CMOS imaging process (SSE 2009). To the best of our knowledge, the DCR (Dark Count Rate) per unit area achieved in these devices is the lowest ever reported in deep sub-micron CMOS SPADs.


[MEGAFRAME] May 2009: MEGAFRAME reports on the real-time hardware (FPGA) implementation of a new integration based FLIM lifetime calculation algorithm, called IEM, suitable for SPAD arrays (see ISCAS 2009). This approach enables direct lifetime calculation in parallel for every pixel. To the best of our knowledge, this is the first system that can generate real-time video-rate fluorescence lifetime images.


[MEGAFRAME] April 2009: MEGAFRAME was selected as one of the exhibits of the FET09 Science beyond Fiction conference, 21-23 April 2009, Prague. E. Charbon and R. Henderson attended and presented a 3 part poster (poster 1 - poster 2 - poster 3).


[MEGAFRAME] Jan. 2009: Dr. Robert Henderson, UNIED, has been invited to present a talk at the Rank Prize mini-symposium on Single-Photon Detectors, 12-15 Jan 2009, Grasmere, Lake District, UK.


[MEGAFRAME] May 2008: MEGAFRAME reports on the direct integration for lifetime extraction method (IEM), a new, simple, and hardware-only fluorescence-lifetime-imaging microscopy (FLIM) proposed to implement on-chip lifetime extractions (JOSA A 2008).

"130nm CMOS SPAD", invited presentation at SPIE Optics East (Sept. 2007)

July/Aug. 2007: MEGAFRAME reports on the first implementation of a Single Photon Avalanche Diode (SPAD) in 130 nm complementary metal–oxide–semiconductor (CMOS) technology - see also the JSTQE paper in the "Publications" section.


FBK/ITC press release, Oct. 2006 (original Italian version, English version).


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NOTE and DISCLAIMER: Although we hope that the following list of external links will be useful to you, the list does not pretend to be complete, and we can not provide any warranty for the accuracy or completeness of the information provided by the Websites mentioned. The MEGAFRAME project, which is not affiliated to the listed organisations and which does not endorse any of them in particular, can not be held liable for any use that may be made of this information.

Last update: May 2007



Cordin Company, High Speed Imaging Solutions
DALSA Technology with Vision
DRS Technologies Inc. - Lightning RDTsupTM -SUP High-Speed Digital Camera
DRS Technologies Inc. - Ultra 8 Framing Camera
High Speed Camera - Digital High Speed Video Camera Systems - Weinberger Vision
High Speed Cameras Digital High Speed Video Camera Systems and Accessories.
LaVision - We count on Photons
Olympus Industrial
Parameter AB - Shimadzu’s High-Speed Video Camera
Photron designs and manufactures high-speed digital video cameras and Primatte chromakey software
Princeton Scientific Instruments, Inc.
Shimadzu - North America
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Itronx Imaging Technologies- High-Speed Cameras



Edinburgh Instruments Ltd
PicoQuant - Fluorescence Lifetime Systems, Picosecond Diode Lasers, TCSPC Systems
Picometrics - About fluorescence
Zeptosens Main
Lifetime imaging TCSPC modules and Photon Counters for FLIM, FCS, FRET and more...
DNR Bio-Imaging Systems Advanced technologies for breakthrough results. Manufacturerer of gel documentation and analysis eq



Micro Photon Devices
Accessories for Detectors, Hamamatsu
Princeton Lightwave Advanced Optical Modules and Systems for Emerging Applications


Micro Photonics Inc.
Diagnostic Instruments Products SPOT Boost Microscope Digital Camera
Optronis GmbH - Your Partner for Cameras and Optics



Visualization Society
CO-ME Leading the way in computer-aided and image-guided medical interventions
David A. B. Miller Home Page
Departement Natuur- en Sterrenkunde - Universiteit Utrecht
Institute of Photonics Staff Dr Martin Dawson
Institute of Photonics Staff Dr. John Girkin
James G. Harris - Electrical Engineering Department - Cal Poly
Microsystems Design Group
MIT Lincoln Laboratory
Stuart Kleinfelder
T.G. Etoh, Kinki University



VDI - Photonics21
EUROPA - Rapid - Press Releases
CORDIS FP6 Find a Document FP6 project management documents and guidance
ISTweb - IST Projects
OPERA 2015
Photonics21 - European Technology Platform
Network of Excellence on Micro-optics - NEMO - FP6
Research - Guide to successful communications



Nanospad Homepage
OPERA 2015
Network of Excellence on Micro-optics - NEMO - FP6


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